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Moreover, the vitamin-D3 pathway was identified as one of the major regulators of cathelicidins [179, 180]

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Anabolic agents (teriparatide, abaloparatide, romosozumab) : Increase bone formation, but DPD can remain elevated initially before stabilizing

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

Because Dihexa initiates synaptic structural changes that take hours to days to fully developrather than producing immediate neurotransmitter effectssplitting the daily dose provides no pharmacodynamic advantage